My Feed

Wed, 07 Feb 2024 02:54:57 GMT

I tackled another myth, COVID Is Renamed Influenza. Instead of approaching it from a clinical standpoint, this time I did it from an epidemiological one.

https://icemsg.org/myths/myth-covid-is-renamed-influenza/

If there are any other things that you hear repeatedly from deniers, let me know. I'm always looking for some ideas for that section. I have started on a mask one, but it's a big, tedious project.

This is also the time of year I have to pay for my site to be hosted. I have yet to even raise enough to break even on that cost and everything I do for graphing data and doing analysis is on my own time. If you would like to contribute...gracias.

https://ko-fi.com/maolesen

Thu, 02 Nov 2023 18:07:02 GMT

I really wonder if people ever truly clear COVID. 18 months of detection of it in macrophages is a bad sign in animal models. "We detected replication-competent SARS-CoV-2 in bronchoalveolar fluid (BALF) Mac for up to 18 months after infection."

https://www.nature.com/articles/s41590-023-01661-4

Can macrophages act as a reservoir for viral diseases?

"Due to their long life span and ability to reside in virtually every tissue, macrophages have been proposed to play a critical role in the establishment and persistence of the HIV-1 reservoir."

https://www.frontiersin.org/articles/10.3389/fmicb.2019.02828/full

Thu, 02 Nov 2023 18:06:30 GMT

I really wonder if people ever truly clear COVID. 18 months of detection of it in macrophages is a bad sign in animal models.

"We detected replication-competent SARS-CoV-2 in bronchoalveolar fluid (BALF) Mac for up to 18 months after infection."

https://www.nature.com/articles/s41590-023-01661-4

Can macrophages act as a reservoir for viral diseases?

"Due to their long life span and ability to reside in virtually every tissue, macrophages have been proposed to play a critical role in the establishment and persistence of the HIV-1 reservoir."

https://www.frontiersin.org/articles/10.3389/fmicb.2019.02828/full

Wed, 27 Sep 2023 19:02:21 GMT

Healthcare continues to collapse. Here's a warning from Italy, with a likely undercount of 20,000 HCWs affected by long COVID. Will we listen now? We sure didn't when someone in Italy shared the difference in the number of obituaries in their local paper on Feb 9 vs Mar 13, 2020. Links in responses until there is an easier way to thread.

Mon, 25 Sep 2023 00:58:55 GMT

"Despite mild acute infections, 70% of participants harbored SARS-CoV-2 RNA in intestinal mucosal tissue and 52% had nucleocapsid (N) protein in intestinal epithelium ~7 months following COVID-19...Another team detected RNA encoding SARS-CoV-2 spike protein in colorectal tissue collected from five patients with PASC from 158 days to 676 days following the initial COVID-19 illness. These patients were part of a larger group that exhibited evidence of increased T cell activation in the gut and spinal cord via whole-body PET imaging...SARS-CoV-2 reservoir may drive inflammatory, coagulation, microbiome, neuroimmune and other abnormalities in PASC."

Mon, 25 Sep 2023 00:47:37 GMT

I was today years old when I learned about transparent mice.

"Our results revealed the accumulation of the spike protein in the skull marrow, brain meninges, and brain parenchyma. The injection of the spike protein alone caused cell death in the brain, highlighting a direct effect on brain tissue. Furthermore, we observed the presence of spike protein in the skull of deceased long after their COVID-19 infection, suggesting that the spike’s persistence may contribute to long-term neurological symptoms."

Mon, 25 Sep 2023 00:45:55 GMT

I was today years old when I learned about transparent mice.

www.biorxiv.org/content/10.1101/2023.04.04.535604v1

Sun, 24 Sep 2023 18:46:00 GMT

"We have demonstrated the longest recorded shedding of fecal SARS-CoV-2 RNA in any COVID-19 patient: ∼210 days post-infection in two participants. Furthermore, we have found that extended shedding of SARS-CoV-2 RNA in participants who no longer have detectable viral RNA in OP swabs is closely associated with a host of systemic and GI symptoms, providing further evidence of a SARS-CoV-2 infection of the gut."

Sun, 24 Sep 2023 18:17:19 GMT

"Immunofluorescence and PCR analyses of intestinal biopsies obtained from asymptomatic individuals at 4 months after the onset of coronavirus disease 2019 (COVID-19) revealed the persistence of SARS-CoV-2 nucleic acids and immunoreactivity in the small bowel of 7 out of 14 individuals. We conclude that the memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence."

Sun, 24 Sep 2023 18:16:45 GMT

Sun, 24 Sep 2023 18:15:45 GMT

Sun, 24 Sep 2023 18:03:21 GMT

"This is the first report of long-term (>100 days) persistence of SARS-CoV-2 RNA in lung tissue of an immunocompetent patient after convalescing from COVID-19. The debris-like tissue that contained SARS-CoV-2 RNA might be composed of degenerated endothelial cells that had detached from vessel walls, dysmorphic syncytial elements of pneumocytes, or dead neutrophilic plugs in the interstitium. We speculate that this debris-like tissue might shield SARS-CoV-2 RNA from degradation."

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00240-X/fulltext

Sun, 24 Sep 2023 17:20:05 GMT

"We found that SARS-CoV-2 infection may result in persistent T cell activation in a variety of body tissues. In some individuals, this activity may persist for years following initial symptom onset and associate with systemic changes in immune activation as well as the presence of Long COVID symptoms. Finally, we found that SARS-CoV-2 persistence in gut tissue may contribute to these processes. Taken together, these observations suggest that even remote, clinically mild SARS-CoV-2 infection could have long-term consequences on tissue-based immune homeostasis."

https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v1.full

Sun, 24 Sep 2023 17:19:54 GMT

Sun, 24 Sep 2023 17:19:42 GMT

Sun, 24 Sep 2023 17:16:42 GMT

https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v1.full

Sun, 24 Sep 2023 17:16:36 GMT

https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v1.full