https://blue.feedland.org/?river=http://data.feedland.org/blue/feeds/Dirk_Remus.xml It's just a feed for now Thu, 03 Oct 2024 03:49:19 GMT feedland v0.6.43 https://cyber.harvard.edu/rss/rss.html Thu, 03 Oct 2024 03:49:18 GMT http://rpc.rsscloud.io:5337/pleaseNotify Wed, October 2, 2024 11:49 PM EDT <p>Happy to announce a new preprint from our lab in collaboration with Richard Hite&#39;s lab at Sloan Kettering Institute:<a href="https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1">https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1</a>.</p> <p>We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation.</p> <p>Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase.</p> <p>This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab, with additional support from members of the Remus and Marians labs.</p> Thu, 03 Oct 2024 03:49:19 GMT https://blue.feedland.org/?item=646579 https://blue.feedland.org/?item=646579 Happy to announce a new preprint from our lab in collaboration with Richard Hite's lab at Sloan Kettering Institute:https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1. We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase. This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab, with additional support from members of the Remus and Marians labs. <p>Happy to announce a new preprint from our lab in collaboration with Richard Hite&#39;s lab at Sloan Kettering Institute:</p> <p><a href="https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1">https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1</a>.</p> <p>We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation.</p> <p>Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase.</p> <p>This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab.</p> Thu, 03 Oct 2024 03:46:21 GMT https://blue.feedland.org/?item=646573 https://blue.feedland.org/?item=646573 Happy to announce a new preprint from our lab in collaboration with Richard Hite's lab at Sloan Kettering Institute: https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1. We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase. This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab. <p>Happy to announce a new preprint from our lab - another great collaboration with Richard Hite&#39;s lab at Sloan Kettering Institute: <a href="https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1">https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1</a>.</p> <p>We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase.</p> <p>This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab.</p> Thu, 03 Oct 2024 03:35:15 GMT https://blue.feedland.org/?item=646562 https://blue.feedland.org/?item=646562 Happy to announce a new preprint from our lab - another great collaboration with Richard Hite's lab at Sloan Kettering Institute: https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1. We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase. This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab. <p>Happy to announce a new preprint from our lab - another great collaboration with Richard Hite&#39;s lab at Sloan Kettering Institute: <a href="https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1">https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1</a>.</p> <p>We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase.</p> <p>This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab.</p> Thu, 03 Oct 2024 03:32:51 GMT https://blue.feedland.org/?item=646558 https://blue.feedland.org/?item=646558 Happy to announce a new preprint from our lab - another great collaboration with Richard Hite's lab at Sloan Kettering Institute: https://www.biorxiv.org/content/10.1101/2024.10.02.616340v1. We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase. This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab.