https://blue.feedland.org/?river=http://data.feedland.org/blue/feeds/AndKr.xml It's just a feed for now Sun, 05 Jan 2025 19:51:14 GMT feedland v0.6.43 https://cyber.harvard.edu/rss/rss.html Sun, 05 Jan 2025 19:51:14 GMT http://rpc.rsscloud.io:5337/pleaseNotify Sun, January 5, 2025 2:51 PM EST <p>A good start into 2025: <a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9">https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9</a>. High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo.</p> <p>We combined sequential dual-nucleoside pulse labeling and DNA content analysis with two different agent-based mathematical models to map cell cycle phase durations in thymocytes in vivo. We discovered that a stretch model of simultaneous expansion or contraction of G1 and S phases explains steady-state thymocyte cell cycle speed transitions.</p> <p>We showed that thymocyte cell cycle phase progression is heterogeneous and that, in a model of irradiation induced involution followed by endogenous regeneration, cell cycle re-entry and G1 shortening promote thymus regeneration.</p> <p>Taken together, we provide a framework to quantitatively determine cell cycle phase duration in vivo, which can be applied to a broad variety of biological systems.</p> <p>This was a joint effort of our lab and @probertimmodels.bsky.social and great collaborators including @victorgreiff.bsky.social and Michael Meyer-Hermann. Thanks to @dfgpublic.bsky.social for their continuous support!</p> Sun, 05 Jan 2025 19:51:14 GMT https://blue.feedland.org/?item=788059 https://blue.feedland.org/?item=788059 A good start into 2025: https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9. High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo. We combined sequential dual-nucleoside pulse labeling and DNA content analysis with two different agent-based mathematical models to map cell cycle phase durations in thymocytes in vivo. We discovered that a stretch model of simultaneous expansion or contraction of G1 and S phases explains steady-state thymocyte cell cycle speed transitions. We showed that thymocyte cell cycle phase progression is heterogeneous and that, in a model of irradiation induced involution followed by endogenous regeneration, cell cycle re-entry and G1 shortening promote thymus regeneration. Taken together, we provide a framework to quantitatively determine cell cycle phase duration in vivo, which can be applied to a broad variety of biological systems. This was a joint effort of our lab and @probertimmodels.bsky.social and great collaborators including @victorgreiff.bsky.social and Michael Meyer-Hermann. Thanks to @dfgpublic.bsky.social for their continuous support! <p>A good start into 2025: <a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9">https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9</a>. High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo.</p> <p>We combined sequential dual-nucleoside pulse labeling and DNA content analysis with two different agent-based mathematical models to map cell cycle phase durations in thymocytes in vivo. We discovered that a stretch model of simultaneous expansion or contraction of G1 and S phases explains steady-state thymocyte cell cycle speed transitions.</p> <p>We showed that thymocyte cell cycle phase progression is heterogeneous and that, in a model of irradiation induced involution followed by endogenous regeneration, cell cycle re-entry and G1 shortening promote thymus regeneration.</p> <p>Taken together, we provide a framework to quantitatively determine cell cycle phase duration in vivo, which can be applied to a broad variety of biological systems.</p> <p>This was a joint effort of our lab and @probertimmodels.bsky.social and great collaborators including @victorgreiff.bsky.social and Michael Meyer-Hermann. Thanks to @dfgpublic.bsky.social for their continuous support!</p> Sun, 05 Jan 2025 19:51:12 GMT https://blue.feedland.org/?item=788058 https://blue.feedland.org/?item=788058 A good start into 2025: https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01483-9. High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo. We combined sequential dual-nucleoside pulse labeling and DNA content analysis with two different agent-based mathematical models to map cell cycle phase durations in thymocytes in vivo. We discovered that a stretch model of simultaneous expansion or contraction of G1 and S phases explains steady-state thymocyte cell cycle speed transitions. We showed that thymocyte cell cycle phase progression is heterogeneous and that, in a model of irradiation induced involution followed by endogenous regeneration, cell cycle re-entry and G1 shortening promote thymus regeneration. Taken together, we provide a framework to quantitatively determine cell cycle phase duration in vivo, which can be applied to a broad variety of biological systems. This was a joint effort of our lab and @probertimmodels.bsky.social and great collaborators including @victorgreiff.bsky.social and Michael Meyer-Hermann. Thanks to @dfgpublic.bsky.social for their continuous support!